Current Research
Spatial Multi-Omics in Cancer
A primary focus of the Craig Lab is the utilization of spatial transcriptomic technologies to integrate single-cell transcriptomics/proteomics with bulk genomics and transcriptomics in their spatial context. Mutli-modal molecular exploration allows for deeper investigation of important areas in cancer research, such as tumor microenvironment and tumor microbiome.
Current projects include:
- application of Visium/VisiumHD, Xenium, and Codex in glioblastoma (GBM)
- decoding the tumor microenvironment with deep learning through the merge of spatial transcriptomics and histopathology
- Spatial microbiome analysis of solid tumors
Clinical Genetics for Colorectal Cancer
Identification of driver mutations is another vital area of cancer research. Current Craig Lab work in this area include the bioinformatic analysis of germline and somatic genomic variation to elucidate CRC driver mutations in Hispanic patients.
Multi-Omic Analysis of Parkinson’s Disease
Through collaboration with multiple international consortia, the Craig Lab conducts research on potential early detection and progression biomarkers in PD. Projects have utilized bulk and single-cell RNA and ATAC sequencing, as well as both short- and long-read transcriptomic data.